Posted opportunity — confirm at source
INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
National Institutes of Health · RFA-OD-27-003
Up to $200,000
2028-06-15-00-00-00
Confirm exact timezone in the announcement.Independent school districts, For profit organizations other than small businesses, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Native American tribal governments (Federally recognized), County governments, Special district governments, Native American tribal organizations (other than Federally recognized tribal governments), Private institutions of higher education, State governments, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, City or township governments
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 360653
Source ↗ · id
opportunityNumber: RFA-OD-27-003
Source ↗ · opportunityNumber
opportunityTitle: INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle
revision: 4
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":433290,"opportunityId":360653,"cfdaNumber":"93.121","programTitle":"Oral Diseases and Disorders Research"},{"id":433298,"opportunityId":360653,"cfdaNumber":"93.173","programTitle":"Research Related to Deafness and Communication Disorders"},{"id":433288,"opportunityId":360653,"cfdaNumber":"93.233","programTitle":"National Center on Sleep Disorders Research"},{"id":431189,"opportunityId":360653,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support"},{"id":433296,"opportunityId":360653,"cfdaNumber":"93.351","programTitle":"Research Infrastructure Programs"},{"id":433291,"opportunityId":360653,"cfdaNumber":"93.395","programTitle":"Cancer Treatment Research"},{"id":433289,"opportunityId":360653,"cfdaNumber":"93.837","programTitle":"Cardiovascular Diseases Research"},{"id":433302,"opportunityId":360653,"cfdaNumber":"93.838","programTitle":"Lung Diseases Research"},{"id":433297,"opportunityId":360653,"cfdaNumber":"93.839","programTitle":"Blood Diseases and Resources Research"},{"id":433299,"opportunityId":360653,"cfdaNumber":"93.840","programTitle":"Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders"},{"id":433295,"opportunityId":360653,"cfdaNumber":"93.846","programTitle":"Arthritis, Musculoskeletal and Skin Diseases Research"},{"id":433294,"opportunityId":360653,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"},{"id":433292,"opportunityId":360653,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":433300,"opportunityId":360653,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":433293,"opportunityId":360653,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":433301,"opportunityId":360653,"cfdaNumber":"93.879","programTitle":"Medical Library Assistance"},{"id":433303,"opportunityId":360653}]
Source ↗ · cfdas
applicantTypes: [{"id":"05","description":"Independent school districts"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"01","description":"County governments"},{"id":"04","description":"Special district governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"20","description":"Private institutions of higher education"},{"id":"00","description":"State governments"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"23","description":"Small businesses"},{"id":"02","description":"City or township governments"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: 200000
Source ↗ · awardCeiling
responseDate: Jun 15, 2028 12:00:00 AM EDT
Source ↗ · responseDate
responseDateStr: 2028-06-15-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: May 12, 2026 11:21:18 AM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=360653].oppStatus
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