HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network

id: 361334
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opportunityNumber: RFA-NS-26-013
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opportunityTitle: HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network
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revision: 0
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agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
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owningAgencyCode: HHS-NIH11
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cfdas: [{"id":432016,"opportunityId":361334,"cfdaNumber":"93.853","programTitle":"Extramural Research Programs in the Neurosciences and Neurological Disorders"}]
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forecastDesc: <p>The National Institute of Neurological Disorders and Stroke, in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated&nbsp;<a href="https://heal.nih.gov/">NIH Helping to End Addiction Long Term (HEAL) initiative</a> intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for&nbsp; comprehensive ‘omics and physiology dataset generation&nbsp;using primary human tissue across the pain neuraxis.&nbsp;Applications should focus on large-scale, high-throughput data generation and analysis of human genes, epigenome, transcriptome, proteome, metabolome, and phenotyping of neuronal and non-neuronal cells at the single-cell and tissue levels. This NOFO is intended as a continuation of the NIH HEAL Initiative’s&nbsp;<a href="https://sparc.science/about/consortia/precision">Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network</a>.&nbsp;The goal of this research will be to expand the generation and dissemination of comprehensive datasets using primary pain-associated human tissues, incorporate cutting-edge technologies, enhance coverage across multiple pain conditions, and extend integration and harmonization of multimodal outputs. This NOFO will utilize a milestone-driven, cooperative agreement mechanism, in which awarded centers will work collaboratively as a network to develop best practices, optimize protocols, replicate and cross-validate research findings, and collectively build an integrated knowledgebase, with digital resources for the entire pain research&nbsp;and therapeutics development communities. NIH program staff involvement is expected to coordinate alignment with the broader <a href="https://heal.nih.gov/data/heal-data-ecosystem">HEAL Data Sharing Ecosystem</a> and account for evolving priorities to ensure program objectives are achieved.</p><p>Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights into comprehensive ‘omics and physiology dataset generation in primary human tissue are encouraged to consider applying for this NOFO. In addition, applications from collaborating, multidisciplinary teams of neurobiologists, pain biologists, human pain scientists and/or physicians, surgeons, and scientists with expertise in statistics, physics, engineering, and bioinformatics should consider applying to this funding opportunity.</p>
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applicantTypes: [{"id":"23","description":"Small businesses"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"00","description":"State governments"},{"id":"02","description":"City or township governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"04","description":"Special district governments"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"01","description":"County governments"},{"id":"22","description":"For profit organizations other than small businesses"}]
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applicantEligibilityDesc: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government, including the NIH Intramural Program;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
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fundingActivityCategories: [{"id":"HL","description":"Health"}]
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costSharing: false
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lastUpdatedDate: Feb 20, 2026 06:33:01 AM EST
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status: forecasted
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