Posted opportunity — confirm at source
NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)
National Institutes of Health · PA-25-306
See source for award amount
2028-01-07-00-00-00
Confirm exact timezone in the announcement.Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, State governments, Special district governments, Public housing authorities/Indian housing authorities, Private institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, City or township governments, Small businesses, Independent school districts, Native American tribal organizations (other than Federally recognized tribal governments), Others (see text field entitled "Additional Information on Eligibility" for clarification), For profit organizations other than small businesses, Native American tribal governments (Federally recognized), County governments, Public and State controlled institutions of higher education
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 357809
Source ↗ · id
opportunityNumber: PA-25-306
Source ↗ · opportunityNumber
opportunityTitle: NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)
Source ↗ · opportunityTitle
revision: 4
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":426507,"opportunityId":357809,"cfdaNumber":"93.113","programTitle":"Environmental Health"},{"id":426495,"opportunityId":357809,"cfdaNumber":"93.143","programTitle":"NIEHS Superfund Hazardous Substances_Basic Research and Education"},{"id":426501,"opportunityId":357809,"cfdaNumber":"93.172","programTitle":"Human Genome Research"},{"id":426503,"opportunityId":357809,"cfdaNumber":"93.173","programTitle":"Research Related to Deafness and Communication Disorders"},{"id":430956,"opportunityId":357809,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":426491,"opportunityId":357809,"cfdaNumber":"93.233","programTitle":"National Center on Sleep Disorders Research"},{"id":426496,"opportunityId":357809,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":426506,"opportunityId":357809,"cfdaNumber":"93.273","programTitle":"Alcohol Research Programs"},{"id":426497,"opportunityId":357809,"cfdaNumber":"93.279","programTitle":"Drug Use and Addiction Research Programs"},{"id":426494,"opportunityId":357809,"cfdaNumber":"93.286","programTitle":"Discovery and Applied Research for Technological Innovations to Improve Human Health"},{"id":429972,"opportunityId":357809,"cfdaNumber":"93.307","programTitle":"Minority Health and Health Disparities Research"},{"id":426498,"opportunityId":357809,"cfdaNumber":"93.361","programTitle":"Nursing Research"},{"id":430916,"opportunityId":357809,"cfdaNumber":"93.393","programTitle":"Cancer Cause and Prevention Research"},{"id":430917,"opportunityId":357809,"cfdaNumber":"93.394","programTitle":"Cancer Detection and Diagnosis Research"},{"id":430918,"opportunityId":357809,"cfdaNumber":"93.395","programTitle":"Cancer Treatment Research"},{"id":430920,"opportunityId":357809,"cfdaNumber":"93.396","programTitle":"Cancer Biology Research"},{"id":430919,"opportunityId":357809,"cfdaNumber":"93.399","programTitle":"Cancer Control"},{"id":426509,"opportunityId":357809,"cfdaNumber":"93.837","programTitle":"Cardiovascular Diseases Research"},{"id":426492,"opportunityId":357809,"cfdaNumber":"93.838","programTitle":"Lung Diseases Research"},{"id":426493,"opportunityId":357809,"cfdaNumber":"93.839","programTitle":"Blood Diseases and Resources Research"},{"id":426502,"opportunityId":357809,"cfdaNumber":"93.840","programTitle":"Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders"},{"id":430530,"opportunityId":357809,"cfdaNumber":"93.846","programTitle":"Arthritis, Musculoskeletal and Skin Diseases Research"},{"id":426499,"opportunityId":357809,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"},{"id":426508,"opportunityId":357809,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":426504,"opportunityId":357809,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":426500,"opportunityId":357809,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":426505,"opportunityId":357809,"cfdaNumber":"93.879","programTitle":"Medical Library Assistance"},{"id":426510,"opportunityId":357809}]
Source ↗ · cfdas
applicantTypes: [{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"04","description":"Special district governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"20","description":"Private institutions of higher education"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"02","description":"City or township governments"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"01","description":"County governments"},{"id":"06","description":"Public and State controlled institutions of higher education"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"ED","description":"Education"},{"id":"ENV","description":"Environment"},{"id":"HL","description":"Health"},{"id":"ISS","description":"Income Security and Social Services"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: none
Source ↗ · awardCeiling
responseDate: Jan 07, 2028 12:00:00 AM EST
Source ↗ · responseDate
responseDateStr: 2028-01-07-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Sep 04, 2025 02:04:19 PM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=357809].oppStatus
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