Posted opportunity — confirm at source

Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)

National Institutes of Health · RFA-AI-28-031

Award range

Up to $3,500,000

Deadline

2027-05-28-00-00-00

Confirm exact timezone in the announcement.

Eligible applicants

Native American tribal organizations (other than Federally recognized tribal governments), City or township governments, Independent school districts, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, County governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, State governments, Special district governments, Small businesses, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Others (see text field entitled "Additional Information on Eligibility" for clarification), For profit organizations other than small businesses

Geographic eligibility and all attachment-specific conditions require review of the original announcement.

Eligibility details

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Matching funds & resources

Source matching-funds field: Not Required.

Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.

About this opportunity

The purpose of this notice of funding opportunity (NOFO) is to support multidisciplinary consortia of structural biologists, microbiologists, and associated experts to solve complex biological structures related to the prevention, treatment, and cure of HIV and other infectious diseases. Centers are expected to facilitate new collaborations, leverage shared resources, offer services and resources to the research community, and train the next generation of scientists engaged in structural biology of infectious diseases.

Funding geography: Not specified — review source. A funder’s address does not establish eligibility.

Review original source ↗

Funding instrument: Cooperative Agreement. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.

Source fields and evidence

id: 361050
Source ↗ · id

opportunityNumber: RFA-AI-28-031
Source ↗ · opportunityNumber

opportunityTitle: Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle

revision: 4
Source ↗ · revision

agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails

owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode

cfdas: [{"id":435623,"opportunityId":361050,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support"},{"id":431660,"opportunityId":361050,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"}]
Source ↗ · cfdas

applicantTypes: [{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"02","description":"City or township governments"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"01","description":"County governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"04","description":"Special district governments"},{"id":"23","description":"Small businesses"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"22","description":"For profit organizations other than small businesses"}]
Source ↗ · applicantTypes

applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Source ↗ · applicantEligibilityDesc

fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
Source ↗ · fundingInstruments

fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories

awardFloor: none
Source ↗ · awardFloor

awardCeiling: 3500000
Source ↗ · awardCeiling

responseDate: May 28, 2027 12:00:00 AM EDT
Source ↗ · responseDate

responseDateStr: 2027-05-28-00-00-00
Source ↗ · responseDateStr

costSharing: false
Source ↗ · costSharing

lastUpdatedDate: Oct 02, 2026 08:28:06 AM EDT
Source ↗ · lastUpdatedDate

status: posted
Source ↗ · oppHits[id=361050].oppStatus

Source retrieved 10/15/2026 · Revision 4. Always confirm current requirements and dates with the funder. Structured source fields are checked; this is not a determination that every applicant qualifies.

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