Cooperative Program for Modeling Clinical Transplantation

id: 361831
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opportunityNumber: RFA-AI-27-017
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opportunityTitle: Cooperative Program for Modeling Clinical Transplantation
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revision: 0
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agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
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owningAgencyCode: HHS-NIH11
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cfdas: [{"id":432618,"opportunityId":361831,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"}]
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forecastDesc: <p>The National Institute of Allergy and Infectious Diseases (NIAID)&nbsp;will support its mission through the <strong>Cooperative Program for&nbsp;Modeling Clinical Transplantation.&nbsp;</strong>Advancements of new therapeutics and success in human solid organ transplantation will require innovative and clinically translatable <i>in-vitro</i> and <i>in</i>-<i>vivo</i> systems to model local and systemic immune responses. This program seeks applications including new approach methods (NAMs) and/or refined mouse models that together will promote translation of new therapies to clinical practice.&nbsp; Potential NAMs include immune-competent microphysiological systems, organoids, <i>ex-vivo</i> perfused human organs, precision-cut tissue slices, and computational systems biology models.&nbsp;Applicants must propose models designed to overcome known obstacles to clinical translation in existing NAMS and/or mouse models, reduce reliance on nonhuman primates, and demonstrate relevance to clinical outcomes.&nbsp; Emphasis on data sharing will facilitate reproducibility and establishment of standards and best practices to achieve the program goals.&nbsp;Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.</p>
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applicantTypes: [{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"01","description":"County governments"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"00","description":"State governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"02","description":"City or township governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"20","description":"Private institutions of higher education"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"04","description":"Special district governments"},{"id":"23","description":"Small businesses"}]
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applicantEligibilityDesc: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations
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fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
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fundingActivityCategories: [{"id":"HL","description":"Health"}]
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costSharing: false
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lastUpdatedDate: Apr 09, 2026 03:22:14 PM EDT
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status: forecasted
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