A Holistic Approach to Study Non-Addictive Natural Products for Pain Management

id: 362025
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opportunityNumber: PAR-28-009
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opportunityTitle: A Holistic Approach to Study Non-Addictive Natural Products for Pain Management
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revision: 0
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agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
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owningAgencyCode: HHS-NIH11
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cfdas: [{"id":432854,"opportunityId":362025,"cfdaNumber":"93.473","programTitle":"Complementary and Integrative Health - Research Projects"}]
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forecastDesc: <p>The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to support collaborative interdisciplinary research that advances foundational understanding of non-addictive natural products for chronic pain management through a holistic, system-oriented approach. This initiative aligns with the NIH Helping to End Addiction Long-term (HEAL) Initiative by promoting safe, non-addictive, and prevention-oriented strategies for pain relief.</p><p>Chronic pain affects tens of millions of adults in the United States, contributing to disability, diminished quality of life, and significant healthcare costs. Despite widespread public use of natural products, such as botanicals, dietary supplements, and other naturally derived compounds for pain relief, scientific evidence has not kept pace with demand. Existing research often focuses on single molecular targets or isolated pathways, which fail to capture the complex, multisystem actions of these products.</p><p>The scope of natural products under this NOFO includes those commonly used by the public as well as those with emerging usage or therapeutic potential.&nbsp; Research is expected to take a holistic approach that examines how these products influence pain through coordinated biological pathways across the multiple organ systems, such as digestive, immune, vascular, musculoskeletal, lymphatic, metabolic/adipose tissues, and nervous system. &nbsp;Studies should also explore dose optimization based on the principle of hormesis, where low doses may elicit beneficial or adaptive effects while higher doses could be ineffective or harmful.&nbsp;In addition, investigators are encouraged to identify optimal intervention timing that aligns with the dynamic phases of pain and inflammation, thereby maximizing therapeutic outcomes and supporting physiological recovery.</p><p>This program emphasizes rigorous mechanistic studies that generate foundational insights to inform future translational research and guide the development of safe, evidence-based, non-addictive strategies for pain management.&nbsp;</p>
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applicantTypes: [{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"04","description":"Special district governments"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"20","description":"Private institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"02","description":"City or township governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"01","description":"County governments"}]
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applicantEligibilityDesc: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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fundingInstruments: [{"id":"G","description":"Grant"}]
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fundingActivityCategories: [{"id":"HL","description":"Health"}]
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costSharing: false
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lastUpdatedDate: Apr 22, 2026 03:14:13 PM EDT
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status: forecasted
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