forecasted
Selective Precision Targeting (SPoT)
National Institutes of Health · FOR-TR-27-003
See source for award amount
Not specified
Native American tribal governments (Federally recognized), For profit organizations other than small businesses, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), Small businesses, County governments, Public housing authorities/Indian housing authorities, State governments, Independent school districts, Private institutions of higher education
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor. More specifically, the initiative goals are to: Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest Assess biodistribution and off-target effects using a multi-organ microphysiological system Provide evidence of functional cargo activity Determine optimal route of administration Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Cooperative Agreement. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 359852
Source ↗ · id
opportunityNumber: FOR-TR-27-003
Source ↗ · opportunityNumber
opportunityTitle: Selective Precision Targeting (SPoT)
Source ↗ · opportunityTitle
revision: 0
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":429986,"opportunityId":359852,"cfdaNumber":"93.350","programTitle":"National Center for Advancing Translational Sciences"}]
Source ↗ · cfdas
forecastDesc: <p>The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor.</p><p><br></p><p>More specifically, the initiative goals are to:</p><ul><li>Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest</li><li>Assess biodistribution and off-target effects using a multi-organ microphysiological system</li><li>Provide evidence of functional cargo activity</li><li>Determine optimal route of administration</li></ul><p><br></p><p>Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.</p>
Source ↗ · forecastDesc
applicantTypes: [{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"00","description":"State governments"},{"id":"05","description":"Independent school districts"},{"id":"20","description":"Private institutions of higher education"}]
Source ↗ · applicantTypes
fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Jun 27, 2025 01:27:52 PM EDT
Source ↗ · lastUpdatedDate
status: forecasted
Source ↗ · oppHits[id=359852].oppStatus
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