Posted opportunity — confirm at source

NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

National Institutes of Health · PA-25-304

Award range

See source for award amount

Deadline

2028-01-07-00-00-00

Confirm exact timezone in the announcement.

Eligible applicants

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, County governments, Special district governments, State governments, Others (see text field entitled "Additional Information on Eligibility" for clarification), City or township governments, Native American tribal governments (Federally recognized), Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), Small businesses, Independent school districts, Public and State controlled institutions of higher education, Private institutions of higher education, Public housing authorities/Indian housing authorities, For profit organizations other than small businesses

Geographic eligibility and all attachment-specific conditions require review of the original announcement.

Eligibility details

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Matching funds & resources

Source matching-funds field: Not Required.

Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.

About this opportunity

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Funding geography: Not specified — review source. A funder’s address does not establish eligibility.

Review original source ↗

Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.

Source fields and evidence

id: 357807
Source ↗ · id

opportunityNumber: PA-25-304
Source ↗ · opportunityNumber

opportunityTitle: NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle

revision: 4
Source ↗ · revision

agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails

owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode

cfdas: [{"id":426472,"opportunityId":357807,"cfdaNumber":"93.113","programTitle":"Environmental Health"},{"id":426480,"opportunityId":357807,"cfdaNumber":"93.121","programTitle":"Oral Diseases and Disorders Research"},{"id":426485,"opportunityId":357807,"cfdaNumber":"93.143","programTitle":"NIEHS Superfund Hazardous Substances_Basic Research and Education"},{"id":426487,"opportunityId":357807,"cfdaNumber":"93.172","programTitle":"Human Genome Research"},{"id":426469,"opportunityId":357807,"cfdaNumber":"93.173","programTitle":"Research Related to Deafness and Communication Disorders"},{"id":426478,"opportunityId":357807,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":426488,"opportunityId":357807,"cfdaNumber":"93.233","programTitle":"National Center on Sleep Disorders Research"},{"id":426481,"opportunityId":357807,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":426467,"opportunityId":357807,"cfdaNumber":"93.273","programTitle":"Alcohol Research Programs"},{"id":426482,"opportunityId":357807,"cfdaNumber":"93.279","programTitle":"Drug Use and Addiction Research Programs"},{"id":426483,"opportunityId":357807,"cfdaNumber":"93.286","programTitle":"Discovery and Applied Research for Technological Innovations to Improve Human Health"},{"id":429963,"opportunityId":357807,"cfdaNumber":"93.307","programTitle":"Minority Health and Health Disparities Research"},{"id":426470,"opportunityId":357807,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support"},{"id":434599,"opportunityId":357807,"cfdaNumber":"93.350","programTitle":"National Center for Advancing Translational Sciences"},{"id":426484,"opportunityId":357807,"cfdaNumber":"93.361","programTitle":"Nursing Research"},{"id":430914,"opportunityId":357807,"cfdaNumber":"93.393","programTitle":"Cancer Cause and Prevention Research"},{"id":430912,"opportunityId":357807,"cfdaNumber":"93.394","programTitle":"Cancer Detection and Diagnosis Research"},{"id":430915,"opportunityId":357807,"cfdaNumber":"93.395","programTitle":"Cancer Treatment Research"},{"id":430911,"opportunityId":357807,"cfdaNumber":"93.396","programTitle":"Cancer Biology Research"},{"id":430913,"opportunityId":357807,"cfdaNumber":"93.399","programTitle":"Cancer Control"},{"id":426476,"opportunityId":357807,"cfdaNumber":"93.837","programTitle":"Cardiovascular Diseases Research"},{"id":426471,"opportunityId":357807,"cfdaNumber":"93.838","programTitle":"Lung Diseases Research"},{"id":426468,"opportunityId":357807,"cfdaNumber":"93.839","programTitle":"Blood Diseases and Resources Research"},{"id":426473,"opportunityId":357807,"cfdaNumber":"93.840","programTitle":"Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders"},{"id":430529,"opportunityId":357807,"cfdaNumber":"93.846","programTitle":"Arthritis, Musculoskeletal and Skin Diseases Research"},{"id":426477,"opportunityId":357807,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"},{"id":426486,"opportunityId":357807,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":426474,"opportunityId":357807,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":426479,"opportunityId":357807,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":426475,"opportunityId":357807,"cfdaNumber":"93.879","programTitle":"Medical Library Assistance"},{"id":426490,"opportunityId":357807}]
Source ↗ · cfdas

applicantTypes: [{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"01","description":"County governments"},{"id":"04","description":"Special district governments"},{"id":"00","description":"State governments"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"02","description":"City or township governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"22","description":"For profit organizations other than small businesses"}]
Source ↗ · applicantTypes

applicantEligibilityDesc: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Source ↗ · applicantEligibilityDesc

fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments

fundingActivityCategories: [{"id":"ED","description":"Education"},{"id":"ENV","description":"Environment"},{"id":"HL","description":"Health"},{"id":"ISS","description":"Income Security and Social Services"}]
Source ↗ · fundingActivityCategories

awardFloor: none
Source ↗ · awardFloor

awardCeiling: none
Source ↗ · awardCeiling

responseDate: Jan 07, 2028 12:00:00 AM EST
Source ↗ · responseDate

responseDateStr: 2028-01-07-00-00-00
Source ↗ · responseDateStr

costSharing: false
Source ↗ · costSharing

lastUpdatedDate: Jul 16, 2026 02:09:43 PM EDT
Source ↗ · lastUpdatedDate

status: posted
Source ↗ · oppHits[id=357807].oppStatus

Source retrieved 10/15/2026 · Revision 4. Always confirm current requirements and dates with the funder. Structured source fields are checked; this is not a determination that every applicant qualifies.

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