forecasted
National Biomedical Research Centers (P50 Clinical Trial Optional)
National Institutes of Health · PAR-28-017
$7,955,376 – $11,405,967
Not specified
Independent school districts, Native American tribal governments (Federally recognized), Small businesses, Native American tribal organizations (other than Federally recognized tribal governments), County governments, For profit organizations other than small businesses, Private institutions of higher education, City or township governments, Others (see text field entitled "Additional Information on Eligibility" for clarification), Special district governments, Public housing authorities/Indian housing authorities, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Public and State controlled institutions of higher education, State governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 362353
Source ↗ · id
opportunityNumber: PAR-28-017
Source ↗ · opportunityNumber
opportunityTitle: National Biomedical Research Centers (P50 Clinical Trial Optional)
Source ↗ · opportunityTitle
revision: 0
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":433277,"opportunityId":362353,"cfdaNumber":"93.351","programTitle":"Research Infrastructure Programs"}]
Source ↗ · cfdas
forecastDesc: <p>The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.</p>
Source ↗ · forecastDesc
applicantTypes: [{"id":"05","description":"Independent school districts"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"01","description":"County governments"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"20","description":"Private institutions of higher education"},{"id":"02","description":"City or township governments"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"04","description":"Special district governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"00","description":"State governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: 7955376
Source ↗ · awardFloor
awardCeiling: 11405967
Source ↗ · awardCeiling
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: May 12, 2026 09:04:18 AM EDT
Source ↗ · lastUpdatedDate
status: forecasted
Source ↗ · oppHits[id=362353].oppStatus
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