Posted opportunity — confirm at source

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

National Institutes of Health · PAR-25-442

Award range

See source for award amount

Deadline

2028-02-17-00-00-00

Confirm exact timezone in the announcement.

Eligible applicants

City or township governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Private institutions of higher education, County governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, For profit organizations other than small businesses, Public housing authorities/Indian housing authorities, State governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Special district governments, Independent school districts, Native American tribal organizations (other than Federally recognized tribal governments), Others (see text field entitled "Additional Information on Eligibility" for clarification), Small businesses

Geographic eligibility and all attachment-specific conditions require review of the original announcement.

Eligibility details

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Matching funds & resources

Source matching-funds field: Not Required.

Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.

About this opportunity

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.

Funding geography: Not specified — review source. A funder’s address does not establish eligibility.

Review original source ↗

Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.

Source fields and evidence

id: 359154
Source ↗ · id

opportunityNumber: PAR-25-442
Source ↗ · opportunityNumber

opportunityTitle: Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle

revision: 5
Source ↗ · revision

agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails

owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode

cfdas: [{"id":428639,"opportunityId":359154,"cfdaNumber":"93.121","programTitle":"Oral Diseases and Disorders Research"},{"id":428636,"opportunityId":359154,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":428637,"opportunityId":359154,"cfdaNumber":"93.350","programTitle":"National Center for Advancing Translational Sciences"},{"id":429802,"opportunityId":359154,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"},{"id":430399,"opportunityId":359154,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":428638,"opportunityId":359154,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":429803,"opportunityId":359154}]
Source ↗ · cfdas

applicantTypes: [{"id":"02","description":"City or township governments"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"20","description":"Private institutions of higher education"},{"id":"01","description":"County governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"00","description":"State governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"04","description":"Special district governments"},{"id":"05","description":"Independent school districts"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"23","description":"Small businesses"}]
Source ↗ · applicantTypes

applicantEligibilityDesc: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Source ↗ · applicantEligibilityDesc

fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments

fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories

awardFloor: none
Source ↗ · awardFloor

awardCeiling: none
Source ↗ · awardCeiling

responseDate: Feb 17, 2028 12:00:00 AM EST
Source ↗ · responseDate

responseDateStr: 2028-02-17-00-00-00
Source ↗ · responseDateStr

costSharing: false
Source ↗ · costSharing

lastUpdatedDate: Jul 29, 2025 08:13:27 AM EDT
Source ↗ · lastUpdatedDate

status: posted
Source ↗ · oppHits[id=359154].oppStatus

Source retrieved 10/15/2026 · Revision 5. Always confirm current requirements and dates with the funder. Structured source fields are checked; this is not a determination that every applicant qualifies.

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