Posted opportunity — confirm at source

BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

National Institutes of Health · RFA-DA-27-004

Award range

See source for award amount

Deadline

2027-11-08-00-00-00

Confirm exact timezone in the announcement.

Eligible applicants

City or township governments, Private institutions of higher education, Small businesses, Independent school districts, Public housing authorities/Indian housing authorities, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, County governments, Others (see text field entitled "Additional Information on Eligibility" for clarification), Special district governments, Native American tribal organizations (other than Federally recognized tribal governments), Native American tribal governments (Federally recognized), Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, For profit organizations other than small businesses, Public and State controlled institutions of higher education, State governments

Geographic eligibility and all attachment-specific conditions require review of the original announcement.

Eligibility details

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Matching funds & resources

Source matching-funds field: Not Required.

Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.

About this opportunity

The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.

Funding geography: Not specified — review source. A funder’s address does not establish eligibility.

Review original source ↗

Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.

Source fields and evidence

id: 359068
Source ↗ · id

opportunityNumber: RFA-DA-27-004
Source ↗ · opportunityNumber

opportunityTitle: BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle

revision: 4
Source ↗ · revision

agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
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owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode

cfdas: [{"id":431110,"opportunityId":359068,"cfdaNumber":"93.173","programTitle":"Research Related to Deafness and Communication Disorders"},{"id":431115,"opportunityId":359068,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":431113,"opportunityId":359068,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":431114,"opportunityId":359068,"cfdaNumber":"93.273","programTitle":"Alcohol Research Programs"},{"id":428545,"opportunityId":359068,"cfdaNumber":"93.279","programTitle":"Drug Use and Addiction Research Programs"},{"id":431112,"opportunityId":359068,"cfdaNumber":"93.286","programTitle":"Discovery and Applied Research for Technological Innovations to Improve Human Health"},{"id":428546,"opportunityId":359068,"cfdaNumber":"93.372","programTitle":"21st Century Cures Act -\tBrain Research through Advancing Innovative Neurotechnologies"},{"id":431118,"opportunityId":359068,"cfdaNumber":"93.853","programTitle":"Extramural Research Programs in the Neurosciences and Neurological Disorders"},{"id":431116,"opportunityId":359068,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":431117,"opportunityId":359068,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":431111,"opportunityId":359068,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":431121,"opportunityId":359068}]
Source ↗ · cfdas

applicantTypes: [{"id":"02","description":"City or township governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"01","description":"County governments"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"04","description":"Special district governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"00","description":"State governments"}]
Source ↗ · applicantTypes

applicantEligibilityDesc: Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Source ↗ · applicantEligibilityDesc

fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments

fundingActivityCategories: [{"id":"ED","description":"Education"},{"id":"HL","description":"Health"},{"id":"ISS","description":"Income Security and Social Services"}]
Source ↗ · fundingActivityCategories

awardFloor: none
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awardCeiling: none
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responseDate: Nov 08, 2027 12:00:00 AM EST
Source ↗ · responseDate

responseDateStr: 2027-11-08-00-00-00
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costSharing: false
Source ↗ · costSharing

lastUpdatedDate: Sep 16, 2025 02:09:58 PM EDT
Source ↗ · lastUpdatedDate

status: posted
Source ↗ · oppHits[id=359068].oppStatus

Source retrieved 10/15/2026 · Revision 4. Always confirm current requirements and dates with the funder. Structured source fields are checked; this is not a determination that every applicant qualifies.

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