Posted opportunity — confirm at source
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
National Institutes of Health · PAR-27-045
See source for award amount
2026-10-30-00-00-00
Confirm exact timezone in the announcement.Public and State controlled institutions of higher education, For profit organizations other than small businesses, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Independent school districts, Public housing authorities/Indian housing authorities, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), State governments, Special district governments, Small businesses, County governments, Others (see text field entitled "Additional Information on Eligibility" for clarification), City or township governments, Native American tribal governments (Federally recognized)
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The NIH Helping to End Addiction Long-term ® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 361304
Source ↗ · id
opportunityNumber: PAR-27-045
Source ↗ · opportunityNumber
opportunityTitle: HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
Source ↗ · opportunityTitle
revision: 4
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":435542,"opportunityId":361304,"cfdaNumber":"93.121","programTitle":"Oral Diseases and Disorders Research"},{"id":431975,"opportunityId":361304,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":435547,"opportunityId":361304,"cfdaNumber":"93.273","programTitle":"Alcohol Research Programs"},{"id":435546,"opportunityId":361304,"cfdaNumber":"93.286","programTitle":"Discovery and Applied Research for Technological Innovations to Improve Human Health"},{"id":435545,"opportunityId":361304,"cfdaNumber":"93.473","programTitle":"Complementary and Integrative Health - Research Projects"},{"id":435544,"opportunityId":361304,"cfdaNumber":"93.846","programTitle":"Arthritis, Musculoskeletal and Skin Diseases Research"},{"id":435543,"opportunityId":361304,"cfdaNumber":"93.853","programTitle":"Extramural Research Programs in the Neurosciences and Neurological Disorders"},{"id":435548,"opportunityId":361304,"cfdaNumber":"93.866","programTitle":"Aging Research"}]
Source ↗ · cfdas
applicantTypes: [{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"00","description":"State governments"},{"id":"04","description":"Special district governments"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"02","description":"City or township governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: none
Source ↗ · awardCeiling
responseDate: Oct 30, 2026 12:00:00 AM EDT
Source ↗ · responseDate
responseDateStr: 2026-10-30-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Sep 28, 2026 08:26:01 AM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=361304].oppStatus
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