Posted opportunity — confirm at source

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

National Institutes of Health · RFA-OD-27-004

Award range

Up to $500,000

Deadline

2028-06-15-00-00-00

Confirm exact timezone in the announcement.

Eligible applicants

County governments, Small businesses, For profit organizations other than small businesses, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal governments (Federally recognized), Independent school districts, Others (see text field entitled "Additional Information on Eligibility" for clarification), State governments, Native American tribal organizations (other than Federally recognized tribal governments), City or township governments, Private institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Public housing authorities/Indian housing authorities, Special district governments, Public and State controlled institutions of higher education

Geographic eligibility and all attachment-specific conditions require review of the original announcement.

Eligibility details

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Matching funds & resources

Source matching-funds field: Not Required.

Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.

About this opportunity

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Funding geography: Not specified — review source. A funder’s address does not establish eligibility.

Review original source ↗

Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.

Source fields and evidence

id: 360654
Source ↗ · id

opportunityNumber: RFA-OD-27-004
Source ↗ · opportunityNumber

opportunityTitle: INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle

revision: 4
Source ↗ · revision

agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails

owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode

cfdas: [{"id":433317,"opportunityId":360654,"cfdaNumber":"93.121","programTitle":"Oral Diseases and Disorders Research"},{"id":433310,"opportunityId":360654,"cfdaNumber":"93.173","programTitle":"Research Related to Deafness and Communication Disorders"},{"id":433322,"opportunityId":360654,"cfdaNumber":"93.233","programTitle":"National Center on Sleep Disorders Research"},{"id":433319,"opportunityId":360654,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":431190,"opportunityId":360654,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support"},{"id":433315,"opportunityId":360654,"cfdaNumber":"93.350","programTitle":"National Center for Advancing Translational Sciences"},{"id":433313,"opportunityId":360654,"cfdaNumber":"93.351","programTitle":"Research Infrastructure Programs"},{"id":433316,"opportunityId":360654,"cfdaNumber":"93.395","programTitle":"Cancer Treatment Research"},{"id":433311,"opportunityId":360654,"cfdaNumber":"93.837","programTitle":"Cardiovascular Diseases Research"},{"id":433320,"opportunityId":360654,"cfdaNumber":"93.838","programTitle":"Lung Diseases Research"},{"id":433314,"opportunityId":360654,"cfdaNumber":"93.839","programTitle":"Blood Diseases and Resources Research"},{"id":433308,"opportunityId":360654,"cfdaNumber":"93.840","programTitle":"Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders"},{"id":433309,"opportunityId":360654,"cfdaNumber":"93.846","programTitle":"Arthritis, Musculoskeletal and Skin Diseases Research"},{"id":433307,"opportunityId":360654,"cfdaNumber":"93.847","programTitle":"Diabetes, Digestive, and Kidney Diseases Extramural Research"},{"id":433312,"opportunityId":360654,"cfdaNumber":"93.855","programTitle":"Allergy and Infectious Diseases Research"},{"id":433318,"opportunityId":360654,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":433306,"opportunityId":360654,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":433305,"opportunityId":360654,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":433321,"opportunityId":360654,"cfdaNumber":"93.879","programTitle":"Medical Library Assistance"},{"id":433323,"opportunityId":360654}]
Source ↗ · cfdas

applicantTypes: [{"id":"01","description":"County governments"},{"id":"23","description":"Small businesses"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"05","description":"Independent school districts"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"02","description":"City or township governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"04","description":"Special district governments"},{"id":"06","description":"Public and State controlled institutions of higher education"}]
Source ↗ · applicantTypes

applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Source ↗ · applicantEligibilityDesc

fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments

fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories

awardFloor: none
Source ↗ · awardFloor

awardCeiling: 500000
Source ↗ · awardCeiling

responseDate: Jun 15, 2028 12:00:00 AM EDT
Source ↗ · responseDate

responseDateStr: 2028-06-15-00-00-00
Source ↗ · responseDateStr

costSharing: false
Source ↗ · costSharing

lastUpdatedDate: May 12, 2026 12:17:45 PM EDT
Source ↗ · lastUpdatedDate

status: posted
Source ↗ · oppHits[id=360654].oppStatus

Source retrieved 10/15/2026 · Revision 4. Always confirm current requirements and dates with the funder. Structured source fields are checked; this is not a determination that every applicant qualifies.

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