Single Source: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Renal and Environmental Science Core (U01-Clinical Trial Not Allowed)

id: 361241
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opportunityNumber: RFA-DK-27-137
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opportunityTitle: Single Source: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Renal and Environmental Science Core (U01-Clinical Trial Not Allowed)
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revision: 0
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agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
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owningAgencyCode: HHS-NIH11
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cfdas: [{"id":431879,"opportunityId":361241,"cfdaNumber":"93.847","programTitle":"Diabetes, Digestive, and Kidney Diseases Extramural Research"}]
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forecastDesc: <p style="margin-left:0in;">The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).</p><p style="margin-left:0in;">Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.</p><p style="margin-left:0in;">NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021.&nbsp;This NOFO requests applications for the Renal and Environmental Science Core&nbsp;that will provide support and leadership in discovery science. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies.&nbsp;</p><p><i>This is a forecast for a single source Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.</i></p><p style="margin-left:0in;">&nbsp;</p>
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applicantTypes: [{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"04","description":"Special district governments"},{"id":"00","description":"State governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"23","description":"Small businesses"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"}]
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applicantEligibilityDesc: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
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fundingActivityCategories: [{"id":"HL","description":"Health"}]
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costSharing: false
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lastUpdatedDate: Feb 05, 2026 01:25:59 PM EST
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status: forecasted
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