forecasted
NIH Pragmatic Trials Conducted in Health Care Systems
National Institutes of Health · PAR-28-010
See source for award amount
Not specified
State governments, Native American tribal governments (Federally recognized), Small businesses, Others (see text field entitled "Additional Information on Eligibility" for clarification), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Independent school districts, County governments, Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Private institutions of higher education, For profit organizations other than small businesses
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The National Institutes of Health intends to publish a Notice of Funding Opportunity (NOFO), Pragmatic and Implementation Trials Conducted in Health Care Settings This funding opportunity will support large-scale pragmatic trials that test intervention effectiveness in routine clinical care and/or implementation trials that evaluate strategies for delivering interventions within health care settings. These trials are intended to directly inform decision-makers (e.g., patients, clinicians, administrators, policymakers, and payers) about the comparative benefits, burdens, and risks of biomedical or behavioral interventions. To enhance real-world relevance and generalizability, applicants are encouraged to: 1) Select care settings where the target condition is commonly seen (e.g., emergency departments, primary care, public health clinics). 2) Include multiple health system types (e.g., academic centers, federally qualified health centers, integrated networks, VA Medical Centers). 3) Assess adaptation across systems and regions to ensure intervention effectiveness and implementation feasibility. Interventions under study should be embedded in routine care. Trials may integrate one or more interventions with established efficacy into appropriate health care settings or implement system-level changes to improve health outcomes. This phased award will use a milestone-driven cooperative agreement mechanism, supporting a planning phase and a phase for full trial execution. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Cooperative Agreement. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 362108
Source ↗ · id
opportunityNumber: PAR-28-010
Source ↗ · opportunityNumber
opportunityTitle: NIH Pragmatic Trials Conducted in Health Care Systems
Source ↗ · opportunityTitle
revision: 0
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":432952,"opportunityId":362108,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":432951,"opportunityId":362108,"cfdaNumber":"93.473","programTitle":"Complementary and Integrative Health - Research Projects"}]
Source ↗ · cfdas
forecastDesc: <p>The National Institutes of Health intends to publish a Notice of Funding Opportunity (NOFO), Pragmatic and Implementation Trials Conducted in Health Care Settings</p><p>This funding opportunity will support large-scale pragmatic trials that test intervention effectiveness in routine clinical care and/or implementation trials that evaluate strategies for delivering interventions within health care settings. These trials are intended to directly inform decision-makers (e.g., patients, clinicians, administrators, policymakers, and payers) about the comparative benefits, burdens, and risks of biomedical or behavioral interventions.</p><p>To enhance real-world relevance and generalizability, applicants are encouraged to: <br>1) Select care settings where the target condition is commonly seen (e.g., emergency departments, primary care, public health clinics). <br>2) Include multiple health system types (e.g., academic centers, federally qualified health centers, integrated networks, VA Medical Centers). <br>3) Assess adaptation across systems and regions to ensure intervention effectiveness and implementation feasibility.</p><p>Interventions under study should be embedded in routine care. Trials may integrate one or more interventions with established efficacy into appropriate health care settings or implement system-level changes to improve health outcomes.</p><p>This phased award will use a milestone-driven cooperative agreement mechanism, supporting a planning phase and a phase for full trial execution.</p><p>Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO. </p>
Source ↗ · forecastDesc
applicantTypes: [{"id":"00","description":"State governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"23","description":"Small businesses"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Apr 29, 2026 06:27:10 AM EDT
Source ↗ · lastUpdatedDate
status: forecasted
Source ↗ · oppHits[id=362108].oppStatus
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