Posted opportunity — confirm at source
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · RFA-NS-27-007
See source for award amount
2029-02-20-00-00-00
Confirm exact timezone in the announcement.Native American tribal governments (Federally recognized), Others (see text field entitled "Additional Information on Eligibility" for clarification), Special district governments, County governments, Public housing authorities/Indian housing authorities, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, City or township governments, State governments, For profit organizations other than small businesses, Native American tribal organizations (other than Federally recognized tribal governments), Independent school districts, Small businesses, Private institutions of higher education
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Cooperative Agreement. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 359161
Source ↗ · id
opportunityNumber: RFA-NS-27-007
Source ↗ · opportunityNumber
opportunityTitle: HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Source ↗ · opportunityTitle
revision: 4
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":434121,"opportunityId":359161,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":434118,"opportunityId":359161,"cfdaNumber":"93.233","programTitle":"National Center on Sleep Disorders Research"},{"id":434117,"opportunityId":359161,"cfdaNumber":"93.273","programTitle":"Alcohol Research Programs"},{"id":434116,"opportunityId":359161,"cfdaNumber":"93.279","programTitle":"Drug Use and Addiction Research Programs"},{"id":434114,"opportunityId":359161,"cfdaNumber":"93.395","programTitle":"Cancer Treatment Research"},{"id":434122,"opportunityId":359161,"cfdaNumber":"93.837","programTitle":"Cardiovascular Diseases Research"},{"id":434123,"opportunityId":359161,"cfdaNumber":"93.838","programTitle":"Lung Diseases Research"},{"id":434120,"opportunityId":359161,"cfdaNumber":"93.839","programTitle":"Blood Diseases and Resources Research"},{"id":434119,"opportunityId":359161,"cfdaNumber":"93.840","programTitle":"Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders"},{"id":434115,"opportunityId":359161,"cfdaNumber":"93.846","programTitle":"Arthritis, Musculoskeletal and Skin Diseases Research"},{"id":428656,"opportunityId":359161,"cfdaNumber":"93.853","programTitle":"Extramural Research Programs in the Neurosciences and Neurological Disorders"},{"id":434124,"opportunityId":359161,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":434125,"opportunityId":359161,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":434126,"opportunityId":359161,"cfdaNumber":"93.867","programTitle":"Vision Research"}]
Source ↗ · cfdas
applicantTypes: [{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"04","description":"Special district governments"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"02","description":"City or township governments"},{"id":"00","description":"State governments"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"05","description":"Independent school districts"},{"id":"23","description":"Small businesses"},{"id":"20","description":"Private institutions of higher education"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: none
Source ↗ · awardCeiling
responseDate: Feb 20, 2029 12:00:00 AM EST
Source ↗ · responseDate
responseDateStr: 2029-02-20-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Jun 16, 2026 11:41:53 AM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=359161].oppStatus
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