Posted opportunity — confirm at source
High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)
National Institutes of Health · RFA-DA-25-060
Up to $1,500,000
2027-03-05-00-00-00
Confirm exact timezone in the announcement.Native American tribal organizations (other than Federally recognized tribal governments), Native American tribal governments (Federally recognized), City or township governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Special district governments, Public housing authorities/Indian housing authorities, County governments, Independent school districts, For profit organizations other than small businesses, Small businesses, Others (see text field entitled "Additional Information on Eligibility" for clarification), Public and State controlled institutions of higher education, State governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 351847
Source ↗ · id
opportunityNumber: RFA-DA-25-060
Source ↗ · opportunityNumber
opportunityTitle: High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)
Source ↗ · opportunityTitle
revision: 3
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":416718,"opportunityId":351847,"cfdaNumber":"93.279","programTitle":"Drug Abuse and Addiction Research Programs"},{"id":416719,"opportunityId":351847}]
Source ↗ · cfdas
applicantTypes: [{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"02","description":"City or township governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"04","description":"Special district governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"00","description":"State governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"20","description":"Private institutions of higher education"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"ED","description":"Education"},{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: 1500000
Source ↗ · awardCeiling
responseDate: Mar 05, 2027 12:00:00 AM EST
Source ↗ · responseDate
responseDateStr: 2027-03-05-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Mar 19, 2026 10:57:27 AM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=351847].oppStatus
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