Posted opportunity — confirm at source
BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-28-010
See source for award amount
2029-02-08-00-00-00
Confirm exact timezone in the announcement.Public housing authorities/Indian housing authorities, Public and State controlled institutions of higher education, Independent school districts, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), County governments, Special district governments, City or township governments, Native American tribal governments (Federally recognized), Small businesses, For profit organizations other than small businesses, State governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), Private institutions of higher education
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
This funding opportunity supports transformative, mechanistic research aimed at understanding how the human brain functions. Applications should seek to reveal how the dynamic activity of individual neurons and ensembles of neurons within spatially organized brain networks gives rise to internal experiences, such as sensations, perceptions, emotions, thoughts, and memories, as well as to observable motor and social behaviors. To achieve fundamental mechanistic insights into human brain function, proposed studies are expected to leverage opportunities made possible by invasive surgical procedures in humans, such as intracranial recording or stimulation. These investigations may be enhanced by incorporating complementary experimental models or systems that provide access to knowledge, techniques, or resources not otherwise available in human neuroscience research. Such integration is encouraged to strengthen the mechanistic understanding of human brain function and to connect discoveries across species and biological scales. This program builds on cutting-edge advances enabled by the BRAIN Initiative and the broader neuroscience community. Projects supported through this opportunity are expected to produce transformative outcomes by the end of the funding period. Approaches should be rigorous, mechanistic, and innovative by (1) maximizing opportunities to conduct innovative in vivo human neuroscience research made available by direct access to the human brain from invasive surgical procedures, (2) employing approaches guided by specified theoretical constructs and/or quantitative, mechanistic models. Funded investigators will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Cooperative Agreement. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 360402
Source ↗ · id
opportunityNumber: RFA-NS-28-010
Source ↗ · opportunityNumber
opportunityTitle: BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle
revision: 4
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":435589,"opportunityId":360402,"cfdaNumber":"93.173","programTitle":"Research Related to Deafness and Communication Disorders"},{"id":435586,"opportunityId":360402,"cfdaNumber":"93.213","programTitle":"Research and Training in Complementary and Integrative Health"},{"id":435585,"opportunityId":360402,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":435590,"opportunityId":360402,"cfdaNumber":"93.273","programTitle":"Alcohol Research Programs"},{"id":435588,"opportunityId":360402,"cfdaNumber":"93.279","programTitle":"Drug Use and Addiction Research Programs"},{"id":435591,"opportunityId":360402,"cfdaNumber":"93.286","programTitle":"Discovery and Applied Research for Technological Innovations to Improve Human Health"},{"id":430758,"opportunityId":360402,"cfdaNumber":"93.372","programTitle":"21st Century Cures Act -\tBrain Research through Advancing Innovative Neurotechnologies"},{"id":430759,"opportunityId":360402,"cfdaNumber":"93.853","programTitle":"Extramural Research Programs in the Neurosciences and Neurological Disorders"},{"id":435584,"opportunityId":360402,"cfdaNumber":"93.865","programTitle":"Child Health and Human Development Extramural Research"},{"id":435587,"opportunityId":360402,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":435583,"opportunityId":360402,"cfdaNumber":"93.867","programTitle":"Vision Research"}]
Source ↗ · cfdas
applicantTypes: [{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"01","description":"County governments"},{"id":"04","description":"Special district governments"},{"id":"02","description":"City or township governments"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"23","description":"Small businesses"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"00","description":"State governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"20","description":"Private institutions of higher education"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"CA","description":"Cooperative Agreement"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: none
Source ↗ · awardCeiling
responseDate: Feb 08, 2029 12:00:00 AM EST
Source ↗ · responseDate
responseDateStr: 2029-02-08-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: Sep 30, 2026 01:51:22 PM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=360402].oppStatus
Related collections: Health funding opportunities · Funding listings with 501(c)(3) nonprofit applicant categories · Funding listings for public higher-education institutions · Funding listings with federally recognized tribal government eligibility ·
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