Posted opportunity — confirm at source
Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-081
See source for award amount
2027-03-05-00-00-00
Confirm exact timezone in the announcement.State governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Small businesses, County governments, Private institutions of higher education, Independent school districts, For profit organizations other than small businesses, Special district governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), Public housing authorities/Indian housing authorities, Native American tribal governments (Federally recognized), Public and State controlled institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), City or township governments
Geographic eligibility and all attachment-specific conditions require review of the original announcement.
Eligibility details
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Matching funds & resources
Source matching-funds field: Not Required.
Matching funds and leveraged resources are different requirements. Read the description and reviewed rules below before determining resource commitments.
About this opportunity
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.
Funding geography: Not specified — review source. A funder’s address does not establish eligibility.
Review original source ↗Funding instrument: Grant. Issuing jurisdiction: Federal. This is not a geographic eligibility determination.
Source fields and evidence
id: 360676
Source ↗ · id
opportunityNumber: PAR-27-081
Source ↗ · opportunityNumber
opportunityTitle: Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
Source ↗ · opportunityTitle
revision: 4
Source ↗ · revision
agencyDetails: {"code":"NIH","seed":"HHS-NIH11","agencyName":"National Institutes of Health","agencyCode":"HHS-NIH11","topAgencyCode":"HHS"}
Source ↗ · agencyDetails
owningAgencyCode: HHS-NIH11
Source ↗ · owningAgencyCode
cfdas: [{"id":433086,"opportunityId":360676,"cfdaNumber":"93.242","programTitle":"Mental Health Research Grants"},{"id":433085,"opportunityId":360676,"cfdaNumber":"93.279","programTitle":"Drug Use and Addiction Research Programs"},{"id":431235,"opportunityId":360676,"cfdaNumber":"93.866","programTitle":"Aging Research"},{"id":433087,"opportunityId":360676,"cfdaNumber":"93.867","programTitle":"Vision Research"},{"id":433103,"opportunityId":360676}]
Source ↗ · cfdas
applicantTypes: [{"id":"00","description":"State governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"04","description":"Special district governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"02","description":"City or township governments"}]
Source ↗ · applicantTypes
applicantEligibilityDesc: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Source ↗ · applicantEligibilityDesc
fundingInstruments: [{"id":"G","description":"Grant"}]
Source ↗ · fundingInstruments
fundingActivityCategories: [{"id":"HL","description":"Health"}]
Source ↗ · fundingActivityCategories
awardFloor: none
Source ↗ · awardFloor
awardCeiling: none
Source ↗ · awardCeiling
responseDate: Mar 05, 2027 12:00:00 AM EST
Source ↗ · responseDate
responseDateStr: 2027-03-05-00-00-00
Source ↗ · responseDateStr
costSharing: false
Source ↗ · costSharing
lastUpdatedDate: May 04, 2026 11:12:12 AM EDT
Source ↗ · lastUpdatedDate
status: posted
Source ↗ · oppHits[id=360676].oppStatus
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